Autism as emergent and transactional

Added on 11/10/2024

Type de contenu

Journal article of the type Perspective ( ; english)

Autism as emergent and transactional published in the journal "Frontiers in psychiatry" Preprint, 14 pages , doi: 10.3389/fpsyt.2022.988755

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Summary/Presentation

The current epistemology of autism as a phenotype derives from the consistency of historical accounts and decades of work within the tradition of descriptive epidemiology, culminating in current categorical descriptions within DSM and ICD nosologies and the concept of “prototypical autism.” The demonstrated high heritability of this phenotype has led to an essentialist theory of autism as a biological entity and the concerted search within the developmental brain and genetic science for discrete biological markers. This search has not revealed simple markers explaining autistic outcomes and has led to moves towards a more dimensional account. This article proposes an alternative transactional approach. It proposes to understand autistic states as an emergent property within a complex developmental system; as the neurodivergent brain, and mind and body, encounter their social and physical environment within early development. Key evidence in support of this approach comes from random allocation intervention trials based on such transactional development theory, both in the infancy pre-diagnostic prodrome and the early post-diagnostic period. In replicated evidence, these intervention trials show that a targeted alteration in the quality of social transactional environment available for the child leads to significant, predictable, and sustained alterations in the outcome dimensional autistic phenotype over time; and further, in one prodromal trial, to a significant reduction in later categorical classification status. The inference from this evidence is that the prototypical autistic phenotype is to a degree malleable with a changed experienced social environment and that it is emergent from its constituent traits. Such a transactional approach enlarges our notion of the phenotype and brings the study of autism within mainstream individual difference developmental science. It challenges essentialist views, for instance as to intrinsic autistic “social avoidance” or theory of mind empathy deficits, integrates dimensional and categorical perspectives, and is consistent with the lived experience of autistic people and their advocacy for improved understanding within a social model.

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(3) Authors whose names are followed by an asterisk have publicly disclosed being autistic.


  • C. Aldred, Jon. Green, C. Adams (2004). "A new social communication intervention for children with autism: pilot randomised controlled treatment study suggesting effectiveness". Child Psychology Psychiatry, 45(8). doi:10.1111/j.1469-7610.2004.00338.x

  • C. Aldred, Jon. Green, R. Emsley, H. McConachie (2012). "Brief Report: Mediation of Treatment Effect in a Communication Intervention for Pre-School Children with Autism". J Autism Dev Disord, 42(3). doi:10.1007/s10803-011-1248-3

  • G. Anderson (2008). "The potential role for emergence in autism". Autism Research, 1(1). doi:10.1002/aur.2

  • G. Anderson (2009). "Conceptualizing Autism: The Role for Emergence". Journal of the American Academy of Child & Adolescent Psychiatry, 48(7). doi:10.1097/chi.0b013e3181a5e3d5

  • D. Astle, J. Holmes, R. Kievit, S. Gathercole (2022). "Annual Research Review: The transdiagnostic revolution in neurodevelopmental disorders". Child Psychology Psychiatry, 63(4). doi:10.1111/jcpp.13481

  • J. Bradshaw, D. Shi, C. Hendrix, C. Saulnier, C. Klaiman (2022). "Neonatal neurobehavior in infants with autism spectrum disorder". Develop Med Child Neuro, 64(5). doi:10.1111/dmcn.15096

  • S. Bryson, L. Zwaigenbaum, C. McDermott, V. Rombough, J. Brian (2008). "The Autism Observation Scale for Infants: Scale Development and Reliability Data". J Autism Dev Disord, 38(4). doi:10.1007/s10803-007-0440-y

  • D. Connaughton, R. Dai, D. Owen, J. Marquez, N. Mann, A. Graham-Paquin, M. Nakayama, E. Coyaud, E. M.N. Laurent, J. St-Germain, L. Snijders Blok, A. Vino, V. Klämbt, K. Deutsch, C. Wilfred Wu, C. Kolvenbach, F. Kause, I. Ottlewski, R. Schneider, T. Kitzler, A. Majmundar, F. Buerger, A. Onuchic-Whitford, M. Youying, A. Kolb, D. Salmanullah, E. Chen, A. van der Ven, J. Rao, H. Ityel, S. Seltzsam, J. Rieke, J. Chen, A. Vivante, D. Hwang, S. Kohl, G. Dworschak, T. Hermle, M. Alders, T. Bartolomaeus, S. Bauer, M. Baum, E. Brilstra, T. Challman, J. Zyskind, C. Costin, K. Dipple, F. Duijkers, M. Ferguson, D. Fitzpatrick, R. Fick, I. Glass, P. Hulick, A. Kline, I. Krey, S. Kumar, W. Lu, E. Marco, I. Wentzensen, H. Mefford, K. Platzer, I. Povolotskaya, J. Savatt, N. Shcherbakova, P. Senguttuvan, A. Squire, D. Stein, I. Thiffault, V. Voinova, M. J.G. Somers, M. Ferguson, A. Traum, G. Daouk, A. Daga, N. Rodig, P. Terhal, E. van Binsbergen, L. Eid, V. Tasic, H. Milo Rasouly, T. Lim, D. Ahram, A. Gharavi, H. Reutter, H. Rehm, D. MacArthur, M. Lek, K. Laricchia, R. Lifton, H. Xu, S. Mane, S. Sanna-Cherchi, A. Sharrocks, B. Raught, S. Fisher, M. Bouchard, M. Khokha, S. Shril, F. Hildebrandt (2020). "Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations". The American Journal of Human Genetics, 107(4). doi:10.1016/j.ajhg.2020.08.013

  • M. Elsabbagh, R. Bruno, M. Wai Wan, T. Charman, M. Johnson*, Jon. Green (2015). "Infant Neural Sensitivity to Dynamic Eye Gaze Relates to Quality of Parent–Infant Interaction at 7-Months in Infants at Risk for Autism". J Autism Dev Disord, 45(2). doi:10.1007/s10803-014-2192-9

  • D. Fein, M. Barton, I. Eigsti, E. Kelley, L. Naigles, R. Schultz, M. Stevens, M. Helt, A. Orinstein, M. Rosenthal, E. Troyb, K. Tyson (2013). "Optimal outcome in individuals with a history of autism". Child Psychology Psychiatry, 54(2). doi:10.1111/jcpp.12037

  • Jon. Green, T. Charman, H. McConachie, C. Aldred, V. Slonims, P. Howlin, A. Le Couteur, K. Leadbitter, K. Hudry, S. Byford, B. Barrett, K. Temple, W. Macdonald, A. Pickles (2010). "Parent-mediated communication-focused treatment in children with autism (PACT): a randomised controlled trial". The Lancet, 375(9732). doi:10.1016/s0140-6736(10)60587-9

  • Jon. Green, K. Leadbitter, C. Ellis, L. Taylor, H. Moore, S. Carruthers, K. James, C. Taylor, M. Balabanovska, S. Langhorne, C. Aldred, V. Slonims, V. Grahame, J. Parr, N. Humphrey, P. Howlin, H. McConachie, A. Le Couteur, T. Charman, R. Emsley, A. Pickles (2022). "Combined social communication therapy at home and in education for young autistic children in England (PACT-G): a parallel, single-blind, randomised controlled trial". The Lancet Psychiatry, 9(4). doi:10.1016/s2215-0366(22)00029-3

  • Jon. Green, A. Pickles, G. Pasco, R. Bedford, M. Wai Wan, M. Elsabbagh, V. Slonims, T. Gliga, E. Jones, C. Cheung, T. Charman, M. Johnson*, I. (2017). "Randomised trial of a parent‐mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years". Child Psychology Psychiatry, 58(12). doi:10.1111/jcpp.12728

  • A. Gulsrud, G. Hellemann, S. F.N. Freeman, C. Kasari (2014). "Two to Ten Years: Developmental Trajectories of Joint Attention in Children With ASD Who Received Targeted Social Communication Interventions". Autism Research, 7(2). doi:10.1002/aur.1360

  • K. Alexandra Havdahl, V. Hus Bal, M. Huerta, A. Pickles, A. Øyen, C. Stoltenberg, C. Lord, S. Bishop (2016). "Multidimensional Influences on Autism Symptom Measures: Implications for Use in Etiological Research". Journal of the American Academy of Child & Adolescent Psychiatry, 55(12). doi:10.1016/j.jaac.2016.09.490

  • T. Insel (2014). "The NIMH Research Domain Criteria (RDoC) Project: Precision Medicine for Psychiatry". AJP, 171(4). doi:10.1176/appi.ajp.2014.14020138

  • C. Jacques, V. Courchesne, S. Mineau, M. Dawson*, L. Mottron (2022). "Positive, negative, neutral—or unknown? The perceived valence of emotions expressed by young autistic children in a novel context suited to autism". Autism, 26(7). doi:10.1177/13623613211068221

  • D. Janvier, Y. Bi Choi, C. Klein, C. Lord, S. Hyun Kim (2022). "Brief Report: Examining Test-Retest Reliability of the Autism Diagnostic Observation Schedule (ADOS-2) Calibrated Severity Scores (CSS)". J Autism Dev Disord, 52(3). doi:10.1007/s10803-021-04952-7

  • V. Jaswal, N. Akhtar (2019). "Being versus appearing socially uninterested: Challenging assumptions about social motivation in autism". Behav Brain Sci, 42. doi:10.1017/s0140525x18001826

  • K. Leadbitter, W. Macdonald, C. Taylor, K. Leneh Buckle*, I. (2020). "Parent perceptions of participation in a parent-mediated communication-focussed intervention with their young child with autism spectrum disorder". Autism, 24(8). doi:10.1177/1362361320936394

  • K. Leadbitter, C. Aldred, H. McConachie, A. Le Couteur, D. Kapadia, T. Charman, W. Macdonald, E. Salomone, R. Emsley, Jon. Green (2018). "The Autism Family Experience Questionnaire (AFEQ): An Ecologically-Valid, Parent-Nominated Measure of Family Experience, Quality of Life and Prioritised Outcomes for Early Intervention". J Autism Dev Disord, 48(4). doi:10.1007/s10803-017-3350-7

  • S. Lloyd-Fox, A. Blasi, C. Elwell, T. Charman, D. Murphy, M. Johnson* (2013). "Reduced neural sensitivity to social stimuli in infants at risk for autism". Proc. R. Soc. B., 280(1758). doi:10.1098/rspb.2012.3026

  • J. Loscalzo, I. Kohane, A. Barabasi (2007). "Human disease classification in the postgenomic era: A complex systems approach to human pathobiology". Molecular Systems Biology, 3(1). doi:10.1038/msb4100163

  • C. Molloy, D. Murray*, R. Akers, T. Mitchell, P. Manning-Courtney (2011). "Use of the Autism Diagnostic Observation Schedule (ADOS) in a clinical setting". Autism, 15(2). doi:10.1177/1362361310379241

  • L. Mottron (2021). "A radical change in our autism research strategy is needed: Back to prototypes". Autism Research, 14(10). doi:10.1002/aur.2494

  • M. Nilsson, P. Handest, L. Nylander, L. Pedersen, J. Carlsson, S. Arnfred (2019). "Arguments for a Phenomenologically Informed Clinical Approach to Autism Spectrum Disorder". Psychopathology, 52(3). doi:10.1159/000500294

  • B. Peterson (2015). "Editorial: Research Domain Criteria (RDoC): a new psychiatric nosology whose time has not yet come". Child Psychology Psychiatry, 56(7). doi:10.1111/jcpp.12439

  • A. Pickles, A. Le Couteur, K. Leadbitter, E. Salomone, R. Cole-Fletcher, H. Tobin, I. Gammer, J. Lowry, G. Vamvakas, S. Byford, C. Aldred, V. Slonims, H. McConachie, P. Howlin, J. Parr, T. Charman, Jon. Green (2016). "Parent-mediated social communication therapy for young children with autism (PACT): long-term follow-up of a randomised controlled trial". The Lancet, 388(10059). doi:10.1016/s0140-6736(16)31229-6

  • A. Pickles, V. Harris, Jon. Green, C. Aldred, H. McConachie, V. Slonims, A. Le Couteur, K. Hudry, T. Charman, I. (2015). "Treatment mechanism in the MRC preschool autism communication trial: implications for study design and parent‐focussed therapy for children". Child Psychology Psychiatry, 56(2). doi:10.1111/jcpp.12291

  • M. Rutter, L. Andersen‐Wood, C. Beckett, D. Bredenkamp, J. Castle, C. Groothues, J. Kreppner, L. Keaveney, C. Lord, T. O'Connor (1999). "Quasi‐autistic Patterns Following Severe Early Global Privation". Child Psychology Psychiatry, 40(4). doi:10.1111/1469-7610.00472

  • D. Ariel Sher, J. Gibson (2023). "Pioneering, prodigious and perspicacious: Grunya Efimovna Sukhareva's life and contribution to conceptualising autism and schizophrenia". Eur Child Adolesc Psychiatry, 32(3). doi:10.1007/s00787-021-01875-7

  • S. Shultz, A. Klin, W. Jones (2018). "Neonatal Transitions in Social Behavior and Their Implications for Autism". Trends in Cognitive Sciences, 22(5). doi:10.1016/j.tics.2018.02.012

  • L. Sterponi, K. de Kirby, J. Shankey (2015). "Rethinking language in autism". Autism, 19(5). doi:10.1177/1362361314537125

  • P. Szatmari, K. Chawarska, G. Dawson, S. Georgiades, R. Landa, C. Lord, D. Messinger, A. Thurm, A. Halladay (2016). "Prospective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions". Journal of the American Academy of Child & Adolescent Psychiatry, 55(3). doi:10.1016/j.jaac.2015.12.014

  • A. Thomas, S. Chess, H. Birch, M. Hertzig, S. Korn (1964). "Behavioral individuality in early childhood.". Journal_inconnu. doi:10.1037/14328-000

  • M. Wai Wan, Jon. Green, M. Elsabbagh, M. Johnson*, T. Charman, F. Plummer, I. (2013). "Quality of interaction between at‐risk infants and caregiver at 12–15 months is associated with 3‐year autism outcome". Child Psychology Psychiatry, 54(7). doi:10.1111/jcpp.12032

  • A. Whitehouse, K. Varcin, S. Pillar, W. Billingham, G. Alvares, J. Barbaro, C. Bent, D. Blenkley, M. Boutrus, A. Chee, L. Chetcuti, A. Clark, E. Davidson, S. Dimov, C. Dissanayake, J. Doyle, M. Grant, C. Green, M. Harrap, T. Iacono, L. Matys, M. Maybery, D. Pope, M. Renton, C. Rowbottam, N. Sadka, L. Segal, V. Slonims, J. Smith, C. Taylor, S. Wakeling, M. Wai Wan, J. Wray, M. Cooper, Jon. Green, K. Hudry (2021). "Effect of Preemptive Intervention on Developmental Outcomes Among Infants Showing Early Signs of Autism". JAMA Pediatr, 175(11). doi:10.1001/jamapediatrics.2021.3298

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